Hong, Xiuqin, Wongtongkam, Nualnong, Ward, Paul Russell, Xiao, Shuiyuan, Wang, Shuling, Peng, Qian, Zuo, Qi, Zeng, Dan, Wang, Jia, Wang, Chenxu, Chen, Jian, and Zhang, Na (2016) An association of serum ALT with elevated blood pressure in senior adults: a case-control study. Clinical and Experimental Hypertension, 38 (8). pp. 691-695.

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Abstract

© 2016 Taylor & Francis. Hypertension is a major risk factor for cardiovascular diseases in China; hence, identifying good serum markers might provide cost benefits in terms of reducing morbidity rates. In this population-based case-control study, participants were recruited from five districts in Hunan province, and 416 cases were matched with an equal number of controls. Markers related to elevated blood pressure were assessed: Body Mass Index, total cholesterol, triglycerides, fasting blood glucose, and creatinine. Three potential serum markers homocysteine (HCY), C-reactive protein (CRP), and alanine aminotransferase (ALT) were dichotomized as normal or high level. Binary logistic regression was used to determine odds ratios (ORs) and 95% confidence intervals (CIs). The findings showed that ALT is a powerful serum marker for predicting high risk of high blood pressure with OR = 2.94, 95% CI (1.44–6.02), while there were no significant differences between cases and controls for HCY and CRP. Additionally, it seems likely that high concentrations of HCY conferred a protective effect against elevated blood pressure. When adjusted for sex, ORs for hypertensive females were nearly five times higher than for hypertensive males (OR = 4.34, 95% CI = 1.17–16.04). The study strongly supports findings showing ALT is a potential indicator for patients with hypertension.

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