Association of demographic, lifestyle factors and serum biomarkers with hypertension in elderly Chinese people

Hong, Xiuqin, Wongtongkam, Nualnong, Ward, Paul Russell, Xiaio, Shuiyuan, Wang, Shuling, Peng, Qian, Zuo, Qi, Zeng, Dan, Wang, Jia, and Wang, Chenxu (2017) Association of demographic, lifestyle factors and serum biomarkers with hypertension in elderly Chinese people. Ageing and Society, 37 (4). pp. 661-674.

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Abstract

Hypertension is a major cause of premature death in China. Understanding risk factors including behavioural and predisposing factors may help to prevent development of hypertension and control the extent of premature mortality. In this case-control design conducted in Hunan province, 416 hypertensive subjects were matched with an equal number of normotensive persons from nearly 9,000 volunteers. A self-report questionnaire was employed to collect demographic and lifestyle information, and fasting serum biomarkers related to lipid profile, renal function, glucose level and uric acid were assessed. When age and sex were stratified, serum biomarkers such as blood urea nitrogen and triglycerides showed a significant difference for hypertension, while lifestyle behaviours including university degree, alcohol use, Body Mass Index and psychological stress (job and married life) were also associated with hypertension. After adjusting for covariate confounding factors, only elevated triglyceride levels were strongly linked to high blood pressure, odds ratio = 1.55, 95 per cent confidence level = 1.16-2.06. To control high blood pressure, hypertriglyceridemia should be included in hypertension treatment and followed up to assess the substantial risk of cardiovascular diseases.

Item ID: 62300
Item Type: Article (Research - C1)
ISSN: 1469-1779
Keywords: Case-control, China, Hypertension, Lifestyle, Serum biomarkers, Triglyceride
Copyright Information: © 2016 Cambridge University Press.
Funders: National Natural Science Foundation of China (NNSFC), Science and Technology Department of Yunnan Province (STDYP), Personnel Training Fund in Hunan province (PTFHP)
Projects and Grants: NNSFC 81202281, STDYP 2011SK3178, PTFHP 2012RS4018
Date Deposited: 24 Feb 2020 01:09
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 30%
42 HEALTH SCIENCES > 4203 Health services and systems > 420301 Aged health care @ 40%
42 HEALTH SCIENCES > 4202 Epidemiology > 420210 Social epidemiology @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 50%
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