Truth behind the appearances: translating new drug therapies to humans

Letson, Hayley L., and Dobson, Geoffrey P. (2019) Truth behind the appearances: translating new drug therapies to humans. Journal of Trauma and Acute Care Surgery, 88 (2). e105-e105.

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Abstract

[Extract] We read with interest the recent study of How et al.1 evaluating adenosine, lidocaine, and magnesium (ALM) therapy in a porcine model of prolonged hemorrhagic shock. The main finding of the study was that ALM was inferior to current Tactical Combat Casualty Care (TCCC) resuscitation in the pig model of controlled bleeding (44% to 60% blood volume loss) with mild hypothermia (36°C).1 This is in direct contrast to our four translational resuscitation studies from rats to pigs since 2012 showing profound benefit after controlled bleeding with up to 75% blood loss,2 endotoxemia,3 and, more recently, after noncompressible hepatic bleeding.4

Item ID: 62095
Item Type: Article (Commentary)
ISSN: 2163-0763
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Copyright Information: © 2020 Lippincott Williams & Wilkins, Inc.
Date Deposited: 04 Mar 2020 04:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110305 Emergency Medicine @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 80%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 90%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 10%
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