Response to letter about ‘Lack of an effective drug for abdominal aortic aneurysm’

Golledge, J., Singh, T.P., Moxon, J.V., Bown, M., Mani, K., and Wanhainen, A. (2020) Response to letter about ‘Lack of an effective drug for abdominal aortic aneurysm’. Journal of Internal Medicine, 288 (1). pp. 152-154. (In Press)

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Abstract

[Extract] Dear Sir, We thank Yu and colleagues for their letter 1 about our recent review 2. We agree there was substantial heterogeneity in the design of the past abdominal aortic aneurysm (AAA) drug trials, particularly those testing antibiotics. Whilst Yu et al. have focused on I2, it should be noted that this describes the dispersion of effect sizes and does not completely describe the heterogeneity between studies. The included antibiotic trials had many methodological variations, such as different sample sizes, durations of antibiotic administration and follow‐up protocols, as outlined in Tables 1 and 2 of our review 2.

Item ID: 62010
Item Type: Article (Commentary)
ISSN: 1365-2796
Copyright Information: © 2019 The Association for the Publication of the Journal of Internal Medicine
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC grant 1098717, NHMRC grant 1079369, NHMRC grant 1022752
Date Deposited: 26 Feb 2020 01:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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