Efficacy of novel indoor residual spraying methods targeting pyrethroid-resistant aedes aegypti within experimental houses

Dunbar, Mike W., Correa-Morales, Fabian, Dzul-Manzanilla, Felipe, Medina-Barreiro, Anuar, Bibiano-Marín, Wilbert, Morales-Ríos, Evaristo, Vadillo-Sánchez, José, López-Monroy, Beatriz, Ritchie, Scott A., Lenhart, Audrey, Manrique-Saide, Pablo, and Vazquez-Prokopec, Gonzalo M. (2019) Efficacy of novel indoor residual spraying methods targeting pyrethroid-resistant aedes aegypti within experimental houses. PLoS Neglected Tropical Diseases, 13 (2). e0007203.

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Abstract

Challenges in maintaining high effectiveness of classic vector control in urban areas has renewed the interest in indoor residual spraying (IRS) as a promising approach for Aedes-borne disease prevention. While IRS has many benefits, application time and intrusive indoor applications make its scalability in urban areas difficult. Modifying IRS to account for Ae. aegypti resting behavior, named targeted IRS (TIRS, spraying walls below 1.5 m and under furniture) can reduce application time; however, an untested assumption is that modifications to IRS will not negatively impact entomological efficacy. We conducted a comparative experimental study evaluating the residual efficacy of classically-applied IRS (as developed for malaria control) compared to two TIRS application methods using a carbamate insecticide against a pyrethroid-resistant, field-derived Ae. aegypti strain. We performed our study within a novel experimental house setting (n = 9 houses) located in Merida (Mexico), with similar layouts and standardized contents. Classic IRS application (insecti-cide applied to full walls and under furniture) was compared to: a) TIRS: insecticide applied to walls below 1.5 m and under furniture, and b) Resting Site TIRS (RS-TIRS): insecticide applied only under furniture. Mosquito mortality was measured eight times post-application (out to six months post-application) by releasing 100 Ae. aegypti females/house and collecting live and dead individuals after 24 hrs exposure. Compared to Classic IRS, TIRS and RS-TIRS took less time to apply (31% and 82% reduction, respectively) and used less insecticide (38% and 85% reduction, respectively). Mortality of pyrethroid-resistant Ae. aegypti did not significantly differ among the three IRS application methods up to two months post application, and did not significantly differ between Classic IRS and TIRS up to four months post application. These data illustrate that optimizing IRS to more efficiently target Ae. aegypti.

Item ID: 61882
Item Type: Article (Research - C1)
ISSN: 1935-2735
Copyright Information: © 2019, Public Library of Science. All rights reserved. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Funders: Emory Global Health Institute (EGHI), Marcus Foundation (MC), Centers for Disease and Prevention (CDC), Consejo Nacional de Ciencia y Tecnología - Mexico (CONACYT), National Health and Medical Research Council (NHMRC)
Projects and Grants: EGHI & MC project #00052002, EGHI Seed Grant project, CDC Project OADS BAA 2016-N- 17844, CONACYT Project # 000000000255141, NHMRC Senior Research Fellowship 1044698
Date Deposited: 19 May 2020 02:41
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111708 Health and Community Services @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100%
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