Metabolomics toward personalized medicine

Jacob, Minnie, Lopata, Andreas L., Dasouki, Majed, and Abdel Rahman, Anas M. (2019) Metabolomics toward personalized medicine. Mass Spectrometry Reviews, 38 (3). pp. 221-238.

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Abstract

Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for biomarker discovery and personalized medicine and has great potential to elucidate the ultimate product of the genomic processes. Over the last decade, metabolomics studies have identified several relevant biomarkers involved in complex clinical phenotypes using diverse biological systems. Most diseases result in signature metabolic profiles that reflect the sums of external and internal cellular activities. Metabolomics has a major role in clinical practice as it represents >95% of the workload in clinical laboratories worldwide. Many of these metabolites require different analytical platforms, such as Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and Ultra Performance Liquid Chromatography (UPLC), while many clinically relevant metabolites are still not routinely amenable to detection using currently available assays. Combining metabolomics with genomics, transcriptomics, and proteomics studies will result in a significantly improved understanding of the disease mechanisms and the pathophysiology of the target clinical phenotype. This comprehensive approach will represent a major step forward toward providing precision medical care, in which individual is accounted for variability in genes, environment, and personal lifestyle. In this review, we compare and evaluate the metabolomics strategies and studies that focus on the discovery of biomarkers that have “personalized” diagnostic, prognostic, and therapeutic value, validated for monitoring disease progression and responses to various management regimens.

Item ID: 61835
Item Type: Article (Research - C1)
ISSN: 1098-2787
Keywords: biomarker discovery, cancer metabolomics, clinical metabolomics, inborn errors of metabolism, mass spectrometry, metabolomics
Copyright Information: © 2017 Wiley Periodicals, Inc.
Funders: King Faisal Hospital and Research Center (KFSHRC)
Date Deposited: 30 Jan 2020 02:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110101 Medical Biochemistry: Amino Acids and Metabolites @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920110 Inherited Diseases (incl. Gene Therapy) @ 50%
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