Genetic predisposition, humans

Jordan, Margaret A., and Baxter, Alan G. (2020) Genetic predisposition, humans. In: Rose, Noel R., and Mackay, Ian R., (eds.) The Autoimmune Diseases. Elsevier, Boston,MA, USA, pp. 383-418.

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Abstract

The translation from genetic knowledge to a molecular understanding of disease is contributing to the development of improved diagnostic and therapeutic products. Here, we briefly cover the localisation of autoimmune disease-associated loci and examine recent progress in molecular understanding of autoimmune disease that has been facilitated by these approaches. We concentrate primarily on progress in the genetics of type 1 diabetes, multiple sclerosis and systemic lupus erythematosus, and draw attention to parallels and contrasts between these diseases, other autoimmune diseases and other immune diseases.

Item ID: 61601
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-12-812102-3
Keywords: Type 1 diabetes; T1D; multiple sclerosis; MS; systemic lupus erythematosus; SLE; lupus; genes; gene loci; molecular mechanisms; functional data; association studies; genetic linkage analysis; genome-wide association studies.
Copyright Information: Copyright © 2020 Elsevier Inc. All rights reserved.
Funders: MS Research Australia (MSRA), Lions Clubs of Australia, National Health and Medical Research Council (NHMRC)
Date Deposited: 05 Jun 2020 12:16
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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