Associations of plasma IGF1, IGFBP3 and estradiol with leucocyte telomere length, a marker of biological age, in men

Yeap, Bu B., Hui, Jennie, Knuiman, Matthew W., Chubb, S.A. Paul, Ho, Ken K.Y., Flicker, Leon, Divitini, Mark L., Arscott, Gillian M., Twigg, Stephen M., Almeida, Osvaldo P., Hankey, Graeme J., Golledge, Jonathan, and Beilby, John P. (2019) Associations of plasma IGF1, IGFBP3 and estradiol with leucocyte telomere length, a marker of biological age, in men. European Journal of Endocrinology, 182 (1). pp. 23-33.

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Abstract

Objective: Effects of insulin-like growth factor 1 (1GF1) and its binding proteins (IGFBPs) on ageing, and their interaction with sex hormones, remain uncertain. We examined associations of plasma IGF1, IGFBP1, IGFBP3, estradiol and testosterone, with leucocyte telomere length (LTL), a marker of biological age, in 2999 community-dwelling men aged 70-84 years.

Methods: Plasma IGF1, IGFBP1 and IGFBP3 measured using immunoassay, sex hormones using mass spectrometry. LTL measured by PCR, expressed as ratio of telomeric to single-copy control gene DNA (T/S ratio). Linear regression models adjusted for age and cardio-metabolic risk factors, median splits defined low/high groups.

Results: Mean age was 76.7 ± 3.2 years. IGF1 and IGFBP3 showed age-adjusted correlations with LTL (coefficient 0.59, P = 0.001 and 0.45, P = 0.013 respectively), IGFBP1 did not. In multivariable-adjusted models IGF1 and IGFBP3 (but not IGFBP1) were associated with LTL (T/S ratio 0.015 higher per 1 S.D. increase in IGF1, P = 0.007, and 0.011 per 1 S.D. IGFBP3, P = 0.049). IGF1 and estradiol were independently associated with longer telomeres (T/S ratio 0.012 higher per 1 S.D. increase in estradiol, P= 0.027, when included in model with IGF1). Testosterone was not associated with LTL. Men with both high IGF1 (>133 μg/L) and high estradiol (>70 pmol/L) had longer LTL compared to men with lower values (multivariable-adjusted T/S ratio 1.20 vs 1.16, P = 0.018).

Conclusions: Higher IGF1 and IGFBP3 are independently associated with longer telomeres in older men. Additive associations of higher IGF1 and higher estradiol with telomere length are present. Further studies are needed to determine whether these hormonal exposures cooperate to slow biological aging.

Item ID: 61504
Item Type: Article (Research - C1)
ISSN: 1479-683X
Copyright Information: © 2019 European Society of Endocrinology.
Funders: National Health and Medical Research Council
Projects and Grants: Project grants: 513823, 1060557 and 1121548
Date Deposited: 22 Jan 2020 07:33
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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