A review of respiratory anatomical development, air flow characterization and particle deposition
Islam, Mohammad S., Paul, Gunther, Ong, Hui X., Young, Paul M., Gu, Y. T., and Saha, Suvash C. (2020) A review of respiratory anatomical development, air flow characterization and particle deposition. International Journal of Environmental Research and Public Health, 17 (2). 380.
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Abstract
The understanding of complex inhalation and transport processes of pollutant particles through the human respiratory system is important for investigations into dosimetry and respiratory health effects in various settings, such as environmental or occupational health. The studies over the last few decades for micro- and nanoparticle transport and deposition have advanced the understanding of drug-aerosol impacts in the mouth-throat and the upper airways. However, most of the Lagrangian and Eulerian studies have utilized the non-realistic symmetric anatomical model for airflow and particle deposition predictions. Recent improvements to visualization techniques using high-resolution computed tomography (CT) data and the resultant development of three dimensional (3-D) anatomical models support the realistic representation of lung geometry. Yet, the selection of different modelling approaches to analyze the transitional flow behavior and the use of different inlet and outlet conditions provide a dissimilar prediction of particle deposition in the human lung. Moreover, incorporation of relevant physical and appropriate boundary conditions are important factors to consider for the more accurate prediction of transitional flow and particle transport in human lung. This review critically appraises currently available literature on airflow and particle transport mechanism in the lungs, as well as numerical simulations with the aim to explore processes involved. Numerical studies found that both the Euler–Lagrange (E-L) and Euler–Euler methods do not influence nanoparticle (particle diameter ≤50 nm) deposition patterns at a flow rate ≤25 L/min. Furthermore, numerical studies demonstrated that turbulence dispersion does not significantly affect nanoparticle deposition patterns. This critical review aims to develop the field and increase the state-of-the-art in human lung modelling.
Item ID: | 61458 |
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Item Type: | Article (Research - C1) |
ISSN: | 1660-4601 |
Keywords: | airflow; particle transport; particle deposition; particle-particle interaction; Euler-Lagrange method; Euler-Euler approach |
Copyright Information: | © 2020 by the authors. This is an Open Access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Projects and Grants: | PR019-8377, BlueSky-2232433 |
Date Deposited: | 16 Jan 2020 02:21 |
FoR Codes: | 46 INFORMATION AND COMPUTING SCIENCES > 4602 Artificial intelligence > 460207 Modelling and simulation @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320103 Respiratory diseases @ 50% |
SEO Codes: | 92 HEALTH > 9202 Health and Support Services > 920203 Diagnostic Methods @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 50% |
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