Anticoagulant heparin mimetics via RAFT polymerization

Al Nahain, Abdullah, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George, and Ferro, Vito (2020) Anticoagulant heparin mimetics via RAFT polymerization. Biomacromolecules, 21 (2). pp. 1009-1021.

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Abstract

Heparin, a sulfated polysaccharide derivedfrom animal sources, is the most commonly used parenteralanticoagulant drug, but it suffers from significant safety andsupply issues. Herein, we describe the preparation of heparinmimetic homo- and copolymers via the reversible addition−fragmentation chain transfer (RAFT) polymerization in waterof commercially available (non-carbohydrate) sulfonated andcarboxylated monomers. The anticoagulant activities of thepolymers were assessed by activated partial thromboplastintime (APTT), thrombin clotting time (TCT), and for the more promising polymers, thrombin generation, antifactor Xa, andantifactor IIa assays. Sulfonated homopolymers studied herein displayed low cytotoxicity and significant anticoagulant activity inAPTT, TCT, and thrombin generation assays. In addition, copolymers of sodium styrenesulfonate and acrylic acid [poly(SSS-co-AA)] displayed unprecedented antifactor IIa activity. This study demonstrates the potential of RAFT polymers as lternativeanticoagulants for biomedical applications.

Item ID: 61353
Item Type: Article (Research - C1)
ISSN: 1526-4602
Copyright Information: Copyright © 2019 American Chemical Society
Funders: Australian Research Council (ARC)
Projects and Grants: ARC DP170104431
Research Data: https://pubs.acs.org/doi/10.1021/acs.biomac.9b01688?goto=supporting-info
Date Deposited: 14 Jan 2020 22:04
FoR Codes: 03 CHEMICAL SCIENCES > 0303 Macromolecular and Materials Chemistry > 030306 Synthesis of Materials @ 75%
11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110102 Medical Biochemistry: Carbohydrates @ 25%
SEO Codes: 81 DEFENCE > 810199 Defence not elsewhere classified @ 34%
86 MANUFACTURING > 8607 Agricultural Chemicals > 860799 Agricultural Chemicals not elsewhere classified @ 33%
92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 33%
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