Anticoagulant heparin mimetics via RAFT polymerization
Al Nahain, Abdullah, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George, and Ferro, Vito (2020) Anticoagulant heparin mimetics via RAFT polymerization. Biomacromolecules, 21 (2). pp. 1009-1021.
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Abstract
Heparin, a sulfated polysaccharide derivedfrom animal sources, is the most commonly used parenteralanticoagulant drug, but it suffers from significant safety andsupply issues. Herein, we describe the preparation of heparinmimetic homo- and copolymers via the reversible addition−fragmentation chain transfer (RAFT) polymerization in waterof commercially available (non-carbohydrate) sulfonated andcarboxylated monomers. The anticoagulant activities of thepolymers were assessed by activated partial thromboplastintime (APTT), thrombin clotting time (TCT), and for the more promising polymers, thrombin generation, antifactor Xa, andantifactor IIa assays. Sulfonated homopolymers studied herein displayed low cytotoxicity and significant anticoagulant activity inAPTT, TCT, and thrombin generation assays. In addition, copolymers of sodium styrenesulfonate and acrylic acid [poly(SSS-co-AA)] displayed unprecedented antifactor IIa activity. This study demonstrates the potential of RAFT polymers as lternativeanticoagulants for biomedical applications.
| Item ID: | 61353 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1526-4602 |
| Copyright Information: | Copyright © 2019 American Chemical Society |
| Funders: | Australian Research Council (ARC) |
| Projects and Grants: | ARC DP170104431 |
| Research Data: | https://pubs.acs.org/doi/10.1021/acs.biomac.9b01688?goto=supporting-info |
| Date Deposited: | 14 Jan 2020 22:04 |
| FoR Codes: | 34 CHEMICAL SCIENCES > 3403 Macromolecular and materials chemistry > 340399 Macromolecular and materials chemistry not elsewhere classified @ 75% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320502 Medical biochemistry - carbohydrates @ 25% |
| SEO Codes: | 81 DEFENCE > 810199 Defence not elsewhere classified @ 34% 86 MANUFACTURING > 8607 Agricultural Chemicals > 860799 Agricultural Chemicals not elsewhere classified @ 33% 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 33% |
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