Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones

Mumtaz, Saira, Robertson, Mark J., and Oelgemöller, Michael (2019) Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones. Molecules, 24 (24). 4527.

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DOI: 10.3390/molecules24244527

View at Publisher Website: https://doi.org/10.3390/molecules2424452...

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Abstract

An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical–thermal–thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.


Item ID:	61170
Item Type:	Article (Research - C1)
ISSN:	1420-3049
Keywords:	photochemistry; photodecarboxylation; phthalimide; continuous-flow photochemistry; multi-step synthesis; arylmethylene isoindolinones
Related URLs:	Publisher
Copyright Information:	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Funders:	Australian Research Council (ARC)
Projects and Grants:	ARC Discovery Project DP130100794
Date Deposited:	12 Dec 2019 01:38
FoR Codes:	34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340503 Organic chemical synthesis @ 60% 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340505 Physical organic chemistry @ 40%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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