Aortic and systemic arterial stiffness responses to acute exercise in patients with small abdominal aortic aneurysms

Perissiou, Maria, Bailey, Tom G., Windsor, Mark, Greaves, Kim, Nam, Michael C.Y, Russell, Fraser D., O'Donnell, Jill, Magee, Rebecca, Jha, Pankaj, Schulze, Karl, Leicht, Anthony S., Golledge, Jonathan, and Askew, Christopher D. (2019) Aortic and systemic arterial stiffness responses to acute exercise in patients with small abdominal aortic aneurysms. European Journal of Vascular and Endovascular Surgery, 58 (5). pp. 708-718.

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Abstract

Objective background: Elevated arterial stiffness is a characteristic of abdominal aortic aneurysm (AAA), and is associated with AAA growth and cardiovascular mortality. A bout of exercise transiently reduces aortic and systemic arterial stiffness in healthy adults. Whether the same response occurs in patients with AAA is unknown. The effect of moderate- and higher intensity exercise on arterial stiffness was assessed in patients with AAA and healthy adults.

Methods: Twenty-two men with small diameter AAAs (36 +/- 5 mm; mean age 74 +/- 6 years) and 22 healthy adults (mean age 72 +/- 5 years) were included. Aortic stiffness was measured using carotid to femoral pulse wave velocity (PWV), and systemic arterial stiffness was estimated from the wave reflection magnitude (RM) and augmentation index (Alx75). Measurements were performed at rest and during 90 min of recovery following three separate test sessions in a randomised order: (i) moderate intensity continuous exercise; (ii) higher intensity interval exercise; or (iii) seated rest.

Results: At rest, PWV was higher in patients with AAA than in healthy adults (p < .001), while Alx75 and RM were similar between groups. No differences were observed between AAA patients and healthy adults in post-exercise aortic and systemic arterial stiffness after either exercise protocol. When assessed as the change from baseline (delta, Delta), post-exercise Delta Alx75 was not different to the seated rest protocol. Conversely, post-exercise Delta PWV and Delta RM were both lower at all time points than seated rest (p < .001). Delta PWV was lower immediately after higher intensity than after moderate intensity exercise (p = .015).

Conclusion: High resting aortic stiffness in patients with AAA is not exacerbated after exercise. There was a similar post-exercise attenuation in arterial stiffness between patients with AAA and healthy adults compared with seated rest. This effect was most pronounced following higher intensity interval exercise, suggesting that this form of exercise may be a safe and effective adjunctive therapy for patients with small AAAs.

Item ID: 61067
Item Type: Article (Research - C1)
ISSN: 1532-2165
Keywords: Pulse-wave velocity, vascular disease, wave reflection characteristics
Copyright Information: © 2019 European Society for Vascular Surgery. Published by Elsevier B.V. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC), Townsville Hopsital, Queensland Government (Senior Clinical Research Fellowship), University of the Sunshine Coast
Projects and Grants: NHMRC 1000967, NHMRC 1022752, NHMRC 1079369, NHMRC 1117061
Date Deposited: 27 Nov 2019 07:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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