New insights into the kinetics and variability of egg excretion in controlled human hookworm infections

Hoogerwerf, Marie-Astrid, Coffeng, Luc E., Brienen, Eric A. T., Janse, Jacqueline J., Langenberg, Marijke C. C., Kruize, Yvonne C. M., Gootjes, Chelsea, Manurung, Mikhael D., Dekker, Mark, Becker, Luke, Erkens, Marianne A.A., van der Beek, Martha T., Ganesh, Munisha S., Feijt, Carola, Winkel, Beatrice M. F., Westra, Inge M., Meij, Pauline, Loukas, Alex, Visser, Leo G., de Vlas, Sake J., Yazdanbakhsh, Maria, van Lieshout, Lisette, and Roestenberg, Meta (2019) New insights into the kinetics and variability of egg excretion in controlled human hookworm infections. Journal of Infectious Diseases, 220 (6). pp. 1044-1048.

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Abstract

Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.

Item ID: 60869
Item Type: Article (Research - C1)
ISSN: 1537-6613
Keywords: hookworm, controlled human infection, Bayesian statistics, vaccine development
Copyright Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders: Dioraphte Foundation, Bill and Melinda Gates Foundation (BMGF), Dutch Society for Scientific Research (DSFSR)
Projects and Grants: BMGF award OPP118434, DSFSR grant 016.Veni.178.023
Date Deposited: 06 Nov 2019 07:50
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
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