Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice

Kraeuter, Ann-Katrin, Archambault, Nadia, van den Buuse, Maarten, and Sarnyai, Zoltan (2019) Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice. Schizophrenia Research, 212. pp. 221-224.

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Abstract

We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.

Item ID: 60865
Item Type: Article (Research - C1)
ISSN: 1573-2509
Keywords: Schizophrenia, Ketogenic diet, Olanzapine, MK-801, NMDA receptors, Prepulse inhibition
Copyright Information: © 2019 Elsevier B.V. All rights reserved.
Funders: James Cook University, National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: JCU Postgraduate Research Scholarship and a Higher Degree Research Enhancement Scheme, NHMRC Senior Research Fellowship
Date Deposited: 06 Nov 2019 07:46
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 100%
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