Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice
Kraeuter, Ann-Katrin, Archambault, Nadia, van den Buuse, Maarten, and Sarnyai, Zoltan (2019) Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice. Schizophrenia Research, 212. pp. 221-224.
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Abstract
We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.
| Item ID: | 60865 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1573-2509 |
| Keywords: | Schizophrenia, Ketogenic diet, Olanzapine, MK-801, NMDA receptors, Prepulse inhibition |
| Copyright Information: | © 2019 Elsevier B.V. All rights reserved. |
| Funders: | James Cook University, National Health and Medical Research Council of Australia (NHMRC) |
| Projects and Grants: | JCU Postgraduate Research Scholarship and a Higher Degree Research Enhancement Scheme, NHMRC Senior Research Fellowship |
| Date Deposited: | 06 Nov 2019 07:46 |
| FoR Codes: | 52 PSYCHOLOGY > 5202 Biological psychology > 520202 Behavioural neuroscience @ 100% |
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