Anti-streptococcal antibody and T-cell interactions with vascular endothelial cells initiate the development of rheumatic carditis

Sikder, Suchandan, Rush, Catherine M., Govan, Brenda L., Alim, Md A., and Ketheesan, Natkunam (2019) Anti-streptococcal antibody and T-cell interactions with vascular endothelial cells initiate the development of rheumatic carditis. Journal of Leukocyte Biology, 107 (2). pp. 263-271.

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The role of group A streptococcal and Streptococcus dysgalactiae subspecies equisimilis M-protein specific Abs and T-cells in endothelial cell activation was investigated using cultured rat aortic endothelial cells, and in a rat model of autoimmune valvulitis. Heat inactivated serum and mononuclear cells from streptococcal M-protein immunized rats independently induced upregulation of the endothelial cell adhesion molecules, vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 in cultured cells. We also observed T-cell migration across endothelial cell monolayers incubated with serum from M-protein-immunized rats. Furthermore, we observed VCAM-1 and ICAM-1 expression in the myocardium of rats injected with M-protein compared to control animals. These observations support the contention that initial interactions between streptococcal M-protein specific Abs and/or T-cells with the heart endothelium lead to endothelial cell activation followed by transmigration of M-protein specific T-cells into heart tissue leading to an inflammatory process that leads to carditis in rheumatic fever and rheumatic heart disease.

Item ID: 60858
Item Type: Article (Research - C1)
ISSN: 0741-5400
Keywords: animal models, group A streptococci, group G streptococci, pathogenesis, post-streptococcal immune complications, rheumatic fever, rheumatic heart disease, Streptococcus dysgalactiae subspecies, equisimilis
Copyright Information: © 2019 Society for Leukocyte Biology.
Funders: Australian National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Grant No. 1026753
Date Deposited: 06 Nov 2019 07:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320402 Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) @ 50%
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