Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men

Carrivick, Simon, Alfonso, Helman, Golledge, Jonathan, Clancy, Paula, Flicker, Leon, Gunton, Jenny E., Hankey, Graeme J., Almeida, Osvaldo P., Norman, Paul E., and Yeap, Bu B. (2019) Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men. Diabetes/Metabolism Research and Reviews, 35 (7). e3172.

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Abstract

Aims: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.

Methods: Cross-sectional analysis of 4153 community-dwelling men aged 70 to 89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D, and glucose were assayed. Diabetes was ascertained from self-report, medications, and fasting glucose.

Results: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1 SD increase in ferritin, P = .006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1 SD, P < .001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, P = .83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR = 0.57, 95% CI = 0.43-0.75, P < .001). There was no interaction between ferritin and vitamin D on diabetes risk.

Conclusions: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions, which raise vitamin D concentrations, would reduce incidence of diabetes in this expanding demographic group.

Item ID: 60851
Item Type: Article (Research - C1)
ISSN: 1520-7560
Keywords: diabetes mellitus, fasting glucose, ferritin, older men, vitamin D
Copyright Information: © 2019 John Wiley & Sons.
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC Grant number 1060557, NHMRC Grant number 1045710, NHMRC Grant number 634492, NHMRC Grant number 513823, NHMRC Grant number 403963, NHMRC Grant number 379600, NHMRC Grant number 279408
Date Deposited: 06 Nov 2019 07:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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