Microwave synthesis of a rare [Ru2L3]4+ triple helicate and its interaction with DNA

Glasson, Christopher R.K., Meehan, George V., Clegg, Jack K., Lindoy, Leonard F., Smith, Jayden A., Keene, F. Richard, and Motti, Cherie (2008) Microwave synthesis of a rare [Ru2L3]4+ triple helicate and its interaction with DNA. Chemistry: a European journal, 14 (34). pp. 10535-10538.

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Abstract

A rare ruthenium(II) triple helicate of the type [Ru2L3]4+ (L=5,5'''-dimethyl-2,2':5',5'':2'',2'''-quaterpyridine) was synthesized in an unusually high yield by using microwave heating in ethylene glycol (see scheme). Efficient separation of the [Ru2L3]4+ helicate into its P and M isomers by DNA affinity chromatography indicated selective binding of P-[Ru2L3]4+ with various DNA sequences.

Item ID: 6074
Item Type: Article (Research - C1)
ISSN: 1521-3765
Keywords: DNA binding; triple helicate; ruthenium; DNA; helicates; metallosupramolecular chemistry; microwave synthesis
Date Deposited: 15 Jan 2010 01:32
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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