Seroprevalence of dengue antibodies in three urban settings in Yucatan, Mexico

Pavía-Ruz, Norma, Rojas, Diana Patricia, Villanueva, Salha, Granja, Pilar, Balam-May, Angel, Longini, Ira M., Halloran, M. Elizabeth, Manrique-Saide, Pablo, and Gómez-Dantés, Hector (2018) Seroprevalence of dengue antibodies in three urban settings in Yucatan, Mexico. American Journal of Tropical Medicine and Hygiene, 98 (4). pp. 1202-1208.

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Abstract

Dengue transmission in Mexico has become a major public health problem. Few epidemiological studies have examined the seroprevalence of dengue in Mexico, and recent estimates are needed to better understand dengue transmission dynamics.Weconducted a dengue seroprevalence survey among 1,668 individuals including all age groups in three urban settings in Yucatan, Mexico. Children (< 19 years old) were selected randomly from schools. The adults (≥ 19 years old) were selected from healthcare facilities. Participants were asked to provide a venous blood sample and to answer a brief questionnaire with demographic information. Previous exposure to dengue was determined using indirect immunoglobulin G enzyme-linked immunosorbent assay. The overall seroprevalence was 73.6%. The age-specific seroprevalence increased with age, going from 51.4% (95% confidence interval [CI] = 45.0-57.9%) in children ≤ 8 years to 72% (95% CI = 66.3-77.2%) in the 9- to 14-years old. The highest seroprevalence was 83.4% (95% CI = 77-82.2%) in adults greater than 50 years. The seroprevalence in Merida was 68.6% (95% CI = 65-72%), in Progreso 68.7% (95% CI = 64.2-72.8%), and in Ticul 85.3% (95% CI = 81.9-88.3%). Ticul had the highest seroprevalence in all age groups. Logistic regression analysis showed that age and city of residence were associated with greater risk of prior dengue exposure. The results highlight the level of past exposure to dengue virus including young children. Similar studies should be conducted elsewhere in Mexico and other endemic countries to better understand the transmission dynamics of deng.

Item ID: 60728
Item Type: Article (Research - C1)
ISSN: 1476-1645
Keywords: Dengue, epidemiology, seroprevalence
Copyright Information: This is an open-access article distributed under the terms of theCreative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided theoriginal author and source are credited
Funders: Yucatan Autonomous University, Hideyo Noguchi, State Public Health Laboratory, Ministry of Health of Yucatan
Date Deposited: 28 Oct 2019 02:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%
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