Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction

Harden, Brandon, Tian, Xin, Giese, Rachel, Nakhleh, Nader, Kureshi, Safina, Francis, Richard, Hanumanthaiah, Sridhar, Li, You, Swisher, Matthew, Kuehl, Karen, Sami, Iman, Olivier, Kenneth, Jonas, Richard, Lo, Cecilia W., and Leatherbury, Linda (2014) Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction. Journal of Thoracic and Cardiovascular Surgery, 147 (4). 1291-U287.

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Abstract

Objective(s): Congenital heart disease (CHD) and heterotaxy patients have increased postoperative and respiratory complications. We recently showed CHD-heterotaxy patients can have respiratory ciliary dysfunction (CD) similar to that associated with primary ciliary dyskinesia, including low nasal nitric oxide and abnormal ciliary motion. In this study, we investigated whether CHD-heterotaxy patients with CD may have worse postsurgical outcomes.

Methods: We examined postsurgical outcome in 13 heterotaxy-CHD patients with CD (25 surgeries), compared with 14 heterotaxy-CHD patients without CD (27 surgeries). Outcome data were collected for each surgery, including respiratory complications, tracheostomy, use of inhaled beta-agonists or nitric oxide, length of hospital stay, days on ventilator, and death.

Results: The CD versus the no-CD CHD cohorts had similar Risk Adjustment in Congenital Heart Surgery-1 risk categories, repair track, age at surgery, and follow-up evaluation times. Respiratory complications (76% vs 37%; P = .006), need for tracheostomy (16% vs 0%; P = .047), and use of inhaled beta-agonists (64% vs 11%; P = .0001) all were increased significantly in heterotaxy-CHD patients with CD. No significant differences were detected in postoperative hospital stay, days on mechanical ventilation, or surgical mortality. A trend toward increased mortality for the CD group beyond the postoperative period was observed (33% vs 0%; P = .055) in patients younger than age 10 years. Conclusions: Our findings showed that heterotaxy-CHD patients with CD may have increased risks for respiratory deficiencies. Overall, there was a trend toward increased mortality in CD patients with intermediate follow-up evaluation. Because b-agonists are known to increase ciliary beat frequency, presurgical screening for CD and perioperative treatment of CD patients with inhaled beta-agonists may improve postoperative outcomes and survival.

Item ID: 60711
Item Type: Article (Research - C1)
ISSN: 1097-685X
Funders: National Institutes of Health (NIH), Children's Medical Research Institute (CMRI), Howard Hughes Medical Institute
Projects and Grants: NIH Z01-HL005701, CMRI 2010-2011
Date Deposited: 23 Oct 2019 12:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110203 Respiratory Diseases @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 35%
11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111401 Foetal Development and Medicine @ 35%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 50%
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