Novel strategy of electrochemical analysis of DNA bases with enhanced performance based on copper−nickel nanosphere decorated N,B−doped reduced graphene oxide

Lei, Peng, Zhou, Ying, Zhu, Ruiqi, Liu, Yang, Dong, Chuan, and Shuang, Shaomin (2020) Novel strategy of electrochemical analysis of DNA bases with enhanced performance based on copper−nickel nanosphere decorated N,B−doped reduced graphene oxide. Biosensors and Bioelectronics, 147. 111735.

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Abstract

Design of suitable nanocomposites with tailored structures was significant in the fabrication of effective and reliable electrochemical sensors. Herein, the copper−nickel@nitrogen, boron−doped reduced graphene oxide (Cu–Ni@N,B−rGO) was successfully synthesized, which exhibited superior electrocatalytic performance towards guanine (G) and adenine (A) oxidation. The Cu–Ni NPs were sequentially decorated on N,B−rGO substrate via an environmentally friendly reduction strategy, which utilized glucose as reducer and stabilizing agent. The nanocomposites with large specific surface area, remarkable conductivity and high catalytic activity showed prominent synergistic effect owning to the uniform dispersion of Cu–Ni NPs on the surface of N,B−rGO. When applied to analysis of G and A using DPV, the wide linear ranges of 1.0–160.0 μM and 1.0–120.0 μM with the determination limits of 0.118 μM and 0.134 μM were obtained, respectively. The sensor was successfully applied to the detection of G and A in calf−thymus DNA with G/A ratio of 0.80. The facile preparation process and attractive sensing properties of the Cu–Ni@N,B−rGO nanocomposites made it a promising candidate for the development of advanced electrochemical sensor.

Item ID: 60651
Item Type: Article (Research - C1)
ISSN: 1873-4235
Keywords: Guanine; Adenine; Synergism; N,B–doped reduced graphene oxide; Electrochemical sensor
Copyright Information: © 2019 Published by Elsevier B.V
Funders: National Natural Science Foundation of China (NNSFC), Natural Science Foundation of Shanxi Province (NSFoSP), Shanxi Province, Shanxi Scholarship Council of China
Projects and Grants: NNSFC 21874087, NSFoSP 201701D221029, Shanxi Province Key R&D project 201803D421031
Date Deposited: 21 Oct 2019 22:42
FoR Codes: 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030102 Electroanalytical Chemistry @ 80%
03 CHEMICAL SCIENCES > 0306 Physical Chemistry (incl Structural) > 030604 Electrochemistry @ 20%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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