Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

Ariyawardana, Anura, Cheng, Karis Kin Fong, Kandwal, Abhishek, Tilly, Vanessa, Al-Azri, Abdul Rahman, Galiti, Dimitra, Chiang, Karen, Vaddi, Anusha, Ranna, Vinisha, Nicolatou-Galitis, Ourania, Lalla, Rajesh V., Bossi, Paolo, Elad, Sharon, and MASCC/ISOO, (2019) Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27. pp. 3985-3995.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Purpose: The aim of this systematic review was to update the clinical practice guidelines for the use of anti-inflammatory agents in the prevention and/or treatment of oral mucositis.

Methods: A systematic review was conducted by the Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology (MASCC/ISOO) subcommittee on mucositis guideline update. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the clinical practice guidelines published in 2014. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guidelines.

Results: A total of 11 new papers across five interventions were examined. The recommendation for the use of benzydamine mouthwash for the prevention of radiotherapy-induced mucositis remained unchanged. New suggestion for the use of the same for prevention of mucositis associated with chemoradiotherapy was made. No guideline was possible for any other antiinflammatory agents due to inadequate and/or conflicting evidence.

Conclusions: Of the anti-inflammatory agents studied for oral mucositis, the evidence supports the use of benzydamine mouthwash in the specific populations listed above. Additional well-designed research is needed on other (class of agents) interventions and in other cancer treatment settings.

Item ID: 60565
Item Type: Article (Research - C1)
ISSN: 1433-7339
Keywords: Oral mucositis, Cancer, Management, Anti-inflammatory agents, Intervention, Guidelines, Radiotherapy, Chemotherapy
Related URLs:
Copyright Information: © Springer-Verlag GmbH Germany, part of Springer Nature 2019.
Additional Information:

Link to the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) in related URL field.

Date Deposited: 02 Oct 2019 07:40
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page