Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

Suttie, Annika, Deng, Yi-Mo, Greenhill, Andrew R., Dussart, Philippe, Horwood, Paul F., and Karlsson, Erik A. (2019) Inventory of molecular markers affecting biological characteristics of avian influenza A viruses. Virus Genes, 55 (6). pp. 739-768.

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Abstract

Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9.

Item ID: 60370
Item Type: Article (Research - C1)
ISSN: 1572-994X
Keywords: Avian influenza, Influenza virus, Molecular marker, Mutation, Risk assessment, Molecular inventory
Copyright Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Funders: US Department of Health and Human Services (US DHHS), Australian Government Department of Education (DoE), Australian Government Department of Health & Ageing, Federation University Australia
Projects and Grants: US DHHS IDSEP140020-01-00, Australian Government Research Training Program Scholarship (RTP)
Date Deposited: 26 Nov 2019 02:44
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070712 Veterinary Virology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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