n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial
Meital, Lara T., Windsor, Mark T., Jewell, Rebecca M. L. Ramirez, Young, Peter, Schulze, Karl, Magee, Rebecca, O'Donnell, Jill, Jha, Pankaj, Perissiou, Maria, Golledge, Jonathan, Bailey, Tom G., Brooks, Peter, Askew, Christopher D., and Russell, Fraser D. (2019) n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial. Journal of Lipid Research, 60 (6). pp. 1154-1163.
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Abstract
Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0-4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 PUFA (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12 week randomized placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid (LA), and AAA and increased 6-desaturase activity and biosynthesis of arachidonic acid (AA) from LA. Omega-3 PUFA supplementation (1.5 g DHA + 0.3 g EPA/day) decreased red blood cell distribution width (14.8 +/- 0.4% to 13.8 +/- 0.2%; P = 0.003) and levels of pro-inflammatory n-6 PUFAs (AA, 12.46 +/- 0.23% to 10.14 +/- 0.3%, P < 0.001; adrenic acid, 2.12 +/- 0.13% to 1.23 +/- 0.09%; P < 0.001). In addition, -4 desaturase activity increased (DHA/docosapentaenoic acid ratio, 1.85 +/- 0.14 to 3.93 +/- 0.17; P < 0.001) and elongase 2/5 activity decreased (adrenic acid/AA ratio, 0.17 +/- 0.01 to 0.12 +/- 0.01; P < 0.01) following supplementation. The findings suggest that n-3 PUFAs improve fatty acid profiles and ameliorate factors associated with inflammation in AAA patients.
| Item ID: | 59977 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1539-7262 |
| Keywords: | omega-3 fatty acids, antioxidants, clinical studies, diet and dietary lipids, diet effects, lipid metabolism, abdominal aortic aneurysms, omega-3 index, polyunsaturated fatty acids |
| Copyright Information: | © 2019 Meital et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. |
| Funders: | Wishlist – Sunshine Coast Health Foundation, University of the Sunshine Coast (USC), National Health and Medical Research Council (NHMRC), Queensland Government (QG) |
| Projects and Grants: | NHMRC Practitioner Fellowship 1117061, QG Senior Clinical Research Fellowship |
| Date Deposited: | 03 Jul 2019 07:32 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100% |
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