Toxic effects of mebendazole at high dose on the haematology of red-legged pademelons (Thylogale stigmatica)

Speare, R., Skerratt, L.F., Berger, L., and Johnson, P.M. (2004) Toxic effects of mebendazole at high dose on the haematology of red-legged pademelons (Thylogale stigmatica). Australian Veterinary Journal, 82 (5). pp. 30-33.

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Abstract

To investigate the effects of mebendazole at high dose on the haematology of macropods.

Design: Experimental.

Procedure: Five red-legged pademelons (Thylogale stigmatica) were dosed orally with mebendazole at 50 mg/kg/d for 5 to 6 days. Two control pademelons were dosed with water. Regular blood samples were taken for haematology over 20 days.

Results: All four treated pademelons sampled at 5 days developed severe leucopenia and neutropenia, moderate lymphopenia, thrombocytopenia, eosinopenia and monocytopenia, as well as bone marrow aplasia within 5 to 11 days after the first mebendazole dose. Four pademelons died unexpectedly or became ill and were euthanased 5 to 11 days after the first dose while the other animal recovered after 5 days of illness. Necropsy revealed systemic infection with opportunistic enteric bacteria, non-suppurative inflammation in tissues, haemorrhage and ulceration of the gastrointestinal tract.

Conclusions: Red-legged pademelons rapidly develop bone-marrow aplasia and subsequent septicaemia after administration of high doses of mebendazole. Mebendazole at high doses should not be used for macropods.

Item ID: 5988
Item Type: Article (Research - C1)
ISSN: 1751-0813
Date Deposited: 15 Feb 2010 23:02
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 100%
SEO Codes: 86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860902 Veterinary Diagnostics @ 100%
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