Coal mine dust lung disease in the modern era

Perret, Jennifer L., Plush, Brian, Lachapelle, Phillippe, Hinks, Timothy S.C., Walter, Clare, Clarke, Phillip, Irving, Louis, Brady, Pat, Dharmage, Shyamali C., and Stewart, Alastair (2017) Coal mine dust lung disease in the modern era. Respirology, 22 (4). pp. 662-670.

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Abstract

Coal workers’ pneumoconiosis (CWP), as part of the spectrum of coal mine dust lung disease (CMDLD), is a preventable but incurable lung disease that can be complicated by respiratory failure and death. Recent increases in coal production from the financial incentive of economic growth lead to higher respirable coal and quartz dust levels, often associated with mechanization of longwall coal mining. In Australia, the observed increase in the number of new CWP diagnoses since the year 2000 has necessitated a review of recommended respirable dust exposure limits, where exposure limits and monitoring protocols should ideally be standardized. Evidence that considers the regulation of engineering dust controls in the mines is lacking even in high‐income countries, despite this being the primary preventative measure. Also, it is a global public health priority for at‐risk miners to be systemically screened to detect early changes of CWP and to include confirmed patients within a central registry; a task limited by financial constraints in less developed countries. Characteristic X‐ray changes are usually categorized using the International Labour Office classification, although future evaluation by low‐dose HRCT) chest scanning may allow for CWP detection and thus avoidance of further exposure, at an earlier stage. Preclinical animal and human organoid‐based models are required to explore potential re‐purposing of anti‐fibrotic and related agents with potential efficacy. Epidemiological patterns and the assessment of molecular and genetic biomarkers may further enhance our capacity to identify susceptible individuals to the inhalation of coal dust in the modern era.

Item ID: 58998
Item Type: Article (Research - C1)
ISSN: 1440-1843
Keywords: coal mine dust lung disease; coal mining; coal workers' pneumoconiosis; health surveillance; respirable dust;
Copyright Information: © 2017 Asian Pacific Society of Respirology
Funders: National Health and Medical Research Council (NHMRC), Wellcome Trust
Projects and Grants: Wellcome Trust Postdoctoral Training Fellowship for Clinicians (104553/z/14/z)
Date Deposited: 25 Jul 2019 04:13
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110203 Respiratory Diseases @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety @ 50%
SEO Codes: 96 ENVIRONMENT > 9601 Air Quality > 960105 Mining Air Quality @ 50%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920504 Occupational Health @ 50%
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