Health-related quality of life in pediatric patients with leukemia in Singapore: a cross-sectional pilot study

Choo, Carol C., Chew, Peter K.H., Tan, Pinhong, Choo, Jessica Q., Choo, Amanda M.H., Ho, Roger C., and Quah, Thuan Chong (2019) Health-related quality of life in pediatric patients with leukemia in Singapore: a cross-sectional pilot study. International Journal of Environmental Research and Public Health, 16 (12). 2069.

PDF (Published version) - Published Version
Available under License Creative Commons Attribution.

Download (300kB) | Preview
View at Publisher Website:


There has been a paradigm shift in health service delivery to a more holistic approach, which considers Quality of Life (QoL) and overall functioning. Health-Related Quality of Life (HRQoL) is a multidimensional construct that encompasses physical functioning as well as psychosocial aspects of emotional and social functioning. This study explored factors related to HRQoL in Asian pediatric patients with leukemia in Singapore. The available variables included: age, treatment duration, household income, gender, ethnicity, religion, diagnosis, and phase of treatment. It is hypothesized that the relationships will be significant. In the current study, there were 60 patients (60% males) with leukemia; their ages ranged from 1 to 21 years (Mean = 8.03, Standard Deviation = 4.55). The hypothesis was partially supported. Age had a significant positive relationship with physical functioning, r(60) = 0.28, p < 0.05, physical health, r(60) = 0.28, p < 0.05, and the total HRQoL score, r(60) = 0.29, p < 0.05. Treatment duration had a positive relationship with school functioning, r(60) = 0.28, p < 0.05. All other correlations were statistically non-significant. The effects of the available psychosocial variables of gender, ethnicity, and religion were examined on scores from the Pediatric Quality of Life Inventory (PedsQL). Ethnicity had a significant effect on social functioning, U = 292.00, p < 0.05, r = 0.3 (medium effect size). Specifically, Chinese (Median = 85.00, n = 33) had significantly higher scores on social functioning than others (Median = 70.00, n = 27). The remaining comparisons were statistically non-significant. The current findings added to QoL research, and provided an impetus for more research in the area of HRQoL for children with leukemia in Singapore.

Item ID: 58896
Item Type: Article (Research - C1)
ISSN: 1660-4601
Keywords: leukemia; pediatric; health-related quality of life; age
Copyright Information: © 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license.
Funders: James Cook University
Projects and Grants: IRG20190003
Date Deposited: 12 Jul 2019 01:02
FoR Codes: 52 PSYCHOLOGY > 5203 Clinical and health psychology > 520304 Health psychology @ 100%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920299 Health and Support Services not elsewhere classified @ 100%
Downloads: Total: 926
Last 12 Months: 10
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page