Facile synthesis of iron phthalocyanine functionalized N,B–doped reduced graphene oxide nanocomposites and sensitive electrochemical detection for glutathione

Lei, Peng, Zhou, Ying, Zhu, Ruiqi, Liu, Yang, Dong, Chuan, and Shuang, Shaomin (2019) Facile synthesis of iron phthalocyanine functionalized N,B–doped reduced graphene oxide nanocomposites and sensitive electrochemical detection for glutathione. Sensors and Actuators B: Chemical, 297. 126756.

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Abstract

Iron phthalocyanine (FePc) functionalized nitrogen, boron–doped reduced graphene oxide (N,B–rGO) nanocomposite (FePc/N,B–rGO) was facilely fabricated for the first time as a electrochemical platform for sensitive detection of glutathione (GSH). FePc was immobilized on N,B–rGO substrate through π–π interaction, and N,B–rGO provided FePc with a large specific surface area to improve electron transfer and maintain its electrocatalytic activity. Cyclic voltammetric measurements showed that FePc and N,B–rGO triggered the synergistic effect and exhibited a satisfactory electrocatalytic activity. By integration of FePc and N,B–rGO, the FePc/N,B–rGO/GCE sensor displayed a wide linear dynamic range from 5.0 × 10–8 M to 1.6 × 10–3 M with a low detection limit of 7.1 × 10–9 M. Besides, the electrochemical sensor presented satisfiable reproducibility, excellent anti–interference performance and long–term stability. The method was further expanded to determinate GSH in human serum sample with the recoveries between 95.0–109.0%.

Item ID: 58841
Item Type: Article (Research - C1)
ISSN: 1873-3077
Keywords: glutathione; iron phthalocyanine; N.B-doped reduced graphene oxide; electrochemical sensor
Copyright Information: © 2019 Published by Elsevier B.V.
Funders: National Natural Science Foundation, China, Natural Science Foundation of Shanxi Province, China
Projects and Grants: NNSFC (21874087), NSFS (201701D221029)
Date Deposited: 09 Jul 2019 05:40
FoR Codes: 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030102 Electroanalytical Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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