Lei, Peng, Zhou, Ying, Zhu, Ruiqi, Liu, Yang, Dong, Chuan, and Shuang, Shaomin (2019) Facile synthesis of iron phthalocyanine functionalized N,B–doped reduced graphene oxide nanocomposites and sensitive electrochemical detection for glutathione. Sensors and Actuators B: Chemical, 297. 126756.

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Abstract

Iron phthalocyanine (FePc) functionalized nitrogen, boron–doped reduced graphene oxide (N,B–rGO) nanocomposite (FePc/N,B–rGO) was facilely fabricated for the first time as a electrochemical platform for sensitive detection of glutathione (GSH). FePc was immobilized on N,B–rGO substrate through π–π interaction, and N,B–rGO provided FePc with a large specific surface area to improve electron transfer and maintain its electrocatalytic activity. Cyclic voltammetric measurements showed that FePc and N,B–rGO triggered the synergistic effect and exhibited a satisfactory electrocatalytic activity. By integration of FePc and N,B–rGO, the FePc/N,B–rGO/GCE sensor displayed a wide linear dynamic range from 5.0 × 10–8 M to 1.6 × 10–3 M with a low detection limit of 7.1 × 10–9 M. Besides, the electrochemical sensor presented satisfiable reproducibility, excellent anti–interference performance and long–term stability. The method was further expanded to determinate GSH in human serum sample with the recoveries between 95.0–109.0%.

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