Patient-reported outcomes after treatment for clinically localized prostate cancer: a systematic review and meta-analysis

Ávila, Mónica, Patel, Laila, López, Silvia, Cortés-Sanabria, Laura, Garin, Olatz, Pont, Àngels, Ferrer, Ferran, Boladeras, Ana, Zamora, Victor, Fosså, Sophie, Storås, Anne H., Sanda, Martin, Serra-Sutton, Vicky, and Ferrer, Montse (2018) Patient-reported outcomes after treatment for clinically localized prostate cancer: a systematic review and meta-analysis. Cancer Treatment Reviews, 66. pp. 23-44.

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Background: The aim of this systematic review is to assess the impact of primary treatments with curative intention in patients with localized prostate cancer, measured with Patient-Reported Outcomes (PROs), and to examine differences among modalities within treatments.

Methods: We conducted a systematic literature search for January 2005-March 2017 following PRISMA guidelines, including longitudinal studies measuring disease-specific PROs in localized prostate cancer patients with a follow-up from pre- to post-treatment (≥1 year). Two reviewers independently extracted data and assessed risk of bias. The study is registered in PROSPERO: CRD42015019747.

Results: Of 148 identified studies, 60 were included in the meta-analyses. At the 1st year, radical prostatectomy patients showed small urinary irritative-obstructive improvement (0.37SD 95%CI 0.30, 0.45), but large deterioration for sexual function and incontinence with high heterogeneity (I2 = 77% and 93%). Moderate worsening in external radiotherapy patients for sexual function (−0.46SD 95%CI −0.55, −0.36), small urinary incontinence (−0.16SD 95%CI −0.23, −0.09) and bowel impairment (−0.31SD 95%CI −0.39, −0.23). Brachytherapy patients presented small deterioration in urinary incontinence (−0.29SD 95%CI −0.39, −0.19), irritative obstructive symptoms (−0.35SD 95%CI −0.47, −0.23), sexual function (−0.12SD 95%CI −0.24, −0.002), and bowel bother (−0.27SD 95%CI −0.42, −0.11). These patterns persisted up to the 5th year. High-intensity focused ultrasound and active surveillance only have results at 1st year, showing no statistically significant worsening.

Conclusions: No remarkable differences in PRO appeared between modalities within each treatment. Nowadays, available evidence supports brachytherapy as possible alternative to radical prostatectomy for patients seeking an attempted curative treatment limiting the risk for urinary incontinence and sexual dysfunction.

Item ID: 58723
Item Type: Article (Research - C1)
ISSN: 1532-1967
Keywords: Meta-analysis; Prostate cancer; Quality of life
Copyright Information: © 2018 Elsevier Ltd
Funders: Instituto de Salud Carlos III (ISC), DIUE of Generalitat de Catalunya (DIUE GC), CIBER of Epidemiology and Public Health CIBERESP
Projects and Grants: ISC grant PI13/00412, DIUE GC grant 2014 SGR 748, DIUE GC grant 2009 SGR 1095
Date Deposited: 18 Jun 2019 23:28
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321104 Cancer therapy (excl. chemotherapy and radiation therapy) @ 100%
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