Letson, Hayley L., and Dobson, Geoffrey Phillip (2019) Response to letter to the editor. Journal of Trauma and Acute Care Surgery, 86 (2). p. 376.

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Abstract

J-T-D-17-07244 Re: The life-saving effect of “adenosine, lidocaine, and magnesium” cocktail during hypovolemic shock: One stone,three birds?

We thank Xiang, Klemcke, and Ryan for their interpretation of our adenosine, lidocaine, and magnesium (ALM) data in rat and pig models of severe hypovolemic shock and for their comments on the potential use of ALM for the treatment of traumatic shock in prehospital or battlefield scenarios. In their analysis, Xiang and colleagues, however, did not mention that ALM also has a profound survival benefit in the rat model of polymicrobial sepsis after 6 days without antibiotics. Thus, unraveling the underlying mechanisms of ALM appears to apply to both hemorrhagicand pathogen-induced traumatic injury and shock. In the June issue of the Journal of Trauma and Acute Care Surgery, we further showed that ALM increases survival after moderate traumatic brain injury.

Item ID:	58722
Item Type:	Article (Scholarly Work)
ISSN:	2163-0763
Copyright Information:	Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Date Deposited:	10 Jul 2019 23:44
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110305 Emergency Medicine @ 50%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 30% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 70%
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