Specific pathogen-free (SPF) animal status as a variable in biomedical research: have we come full circle?

Dobson, Geoffrey P., Letson, Hayley L., Biros, Erik, and Morris, Jodie (2019) Specific pathogen-free (SPF) animal status as a variable in biomedical research: have we come full circle? EBioMedicine, 41. pp. 42-43.

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Abstract

In this commentary, we discuss the pros and cons of using specific pathogen-free (SPF) animals in biomedical research, and present individual cases where altering the gut microbiome has dramatically changed the animal's basic physiology, immune/inflammatory functions and susceptibility to infection and disease. We argue that SPF manipulation of the microbiome-host relationship has itself become a confounding variable in biomedical research, which could have major implications to human translation.

Item ID: 58721
Item Type: Article (Commentary)
ISSN: 2352-3964
Keywords: biomedical research; clinical trial; gut; microbiome; reproducibility; rodent; specific pathogen free; translation
Copyright Information: © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Funders: USSOCOM
Projects and Grants: SO150053 under Award W81XWH-USSOCOM-BAA-15-1
Date Deposited: 10 Jul 2019 23:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 60%
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