Effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair

Rosengren, Helena, Heal, Clare F., and Buttner, Petra G. (2019) Effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair. Dermatology Practical & Conceptual, 9 (1). pp. 28-35.

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Abstract

Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain.

Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose.

Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40–60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia.

Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1).

Conclusion: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.

Item ID: 58698
Item Type: Article (Research - C1)
ISSN: 2160-9381
Keywords: antibiotic prophylaxis, surgical site infection, dermatological surgical wound infection, operative surgical procedures, grafts
Copyright Information: All research articles published in Dermatology Practical & Conceptual are freely and permanently accessible online. Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). The authors retain the copyright for their published work.
Date Deposited: 12 Jul 2019 03:06
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 100%
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