Effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair
Rosengren, Helena, Heal, Clare F., and Buttner, Petra G. (2019) Effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair. Dermatology Practical & Conceptual, 9 (1). pp. 28-35.
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Abstract
Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain.
Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose.
Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40–60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia.
Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1).
Conclusion: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.
| Item ID: | 58698 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2160-9381 |
| Keywords: | antibiotic prophylaxis, surgical site infection, dermatological surgical wound infection, operative surgical procedures, grafts |
| Copyright Information: | All research articles published in Dermatology Practical & Conceptual are freely and permanently accessible online. Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). The authors retain the copyright for their published work. |
| Date Deposited: | 12 Jul 2019 03:06 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320226 Surgery @ 50% 42 HEALTH SCIENCES > 4203 Health services and systems > 420317 Patient safety @ 50% |
| SEO Codes: | 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 100% |
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