Plant alkaloids: classification, isolation and drug development

Wangchuk, Phurpa (2019) Plant alkaloids: classification, isolation and drug development. In: Swamy, Mallappa, Patra, Jayanta, and Rudramurthy, Gudepalya, (eds.) Medicinal Plants: chemistry, pharmacology and therapeutic applications. Taylor & Francis Ltd, Boca Raton, FL, USA, pp. 131-137.

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Plants contain alkaloids that have vast structural diversity with potential for therapeutic applications. Sequestering bioactive alkaloids from plants is a challenging task and it involves plant identification, collection, extraction, isolation, purification, structure elucidation, compound identification, and bioactivity screening. Recent advancements in mass spectrometry and nuclear magnetic resonance spectroscopy have revived the interest of the researchers that helped the discovery of many new bioactive alkaloids. Over 20,000 alkaloids have been isolated to date, out of which approximately 600 alkaloids have been analysed for their biological and medicinal properties. Many of these alkaloids, including taxol- isolated from Taxus brevifolia and quinine- isolated from Cinchona officinalis have become important drugs in the pharmaceutical industry. Recently, numerous drug-like alkaloids have been isolated from plants. For example, simplicifolianine isolated from Meconopsis simplicifolia was identified as a novel antimalarial alkaloid against multi-drug resistant Plasmodium falciparum. This chapter will highlight the history, classification, biological properties, isolation and structure elucidation, and medicinal application of alkaloids by providing case reports on the discovery of new alkaloids and drug leads.

Item ID: 58447
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-367-11172-4
Keywords: Plants; Alkaloids; Isolation; Biological activities; Drug development
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Copyright Information: © 2019 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business
Date Deposited: 02 Jul 2019 04:09
FoR Codes: 34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340499 Medicinal and biomolecular chemistry not elsewhere classified @ 30%
34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340502 Natural products and bioactive compounds @ 40%
34 CHEMICAL SCIENCES > 3401 Analytical chemistry > 340109 Separation science @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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