Diagnosis and management of shellfish allergy: current approach and future needs

Pascal, Mariona, Kamath, Sandip D., and Faber, Margaretha (2018) Diagnosis and management of shellfish allergy: current approach and future needs. Current Treatment Options in Allergy, 5 (4). pp. 470-486.

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Purpose of review: Shellfish allergy is an increasing health concern worldwide with over 2% of the population affected and higher rates in countries with high consumption. Shellfish includes both crustaceans and mollusks and constitutes one of the major food groups triggering allergic reactions.

Recent findings: Shrimp is the best-studied crustacean, in which the major shellfish allergen, tropomyosin, was initially characterized. Nevertheless, several other allergens have been identified and should be considered despite prevalence of sensitization being lower than tropomyosin (e.g., arginine kinase, myosin light chain, and sarcoplasmic calcium-binding protein).

Summary: Diagnosis is not always straightforward; due to the conserved nature of most allergens, there is extensive cross-reactivity between different species which hampers proper diagnosis and management. Clinical symptoms can range from mild local ones to life-threatening anaphylaxis, sometimes with cofactor involvement. Currently, there is no available curative treatment besides diet avoidance and treatment of symptoms in case of accidental exposure.

Item ID: 58102
Item Type: Article (Research - C1)
ISSN: 2196-3053
Keywords: Shellfish, Crustacean, Mollusk, Food allergy, Tropomyosin, Diagnostic
Copyright Information: Copyright © Springer Nature Switzerland AG 2018
Date Deposited: 07 Jun 2019 05:46
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 100%
Downloads: Total: 4
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