Structural, thermal, in vitro degradation and cytocompatibility properties of P₂O₅-B₂O₃-CaO-MgO-Na₂O-Fe₂O₃ glasses

Zhu, Chenkai, Ahmed, Ifty, Parsons, Andy, Hossain, Kazi Zakir, Rudd, Chris, Liu, Jingsong, and Liu, Xiaoling (2017) Structural, thermal, in vitro degradation and cytocompatibility properties of P₂O₅-B₂O₃-CaO-MgO-Na₂O-Fe₂O₃ glasses. Journal of Non-Crystalline Solids, 457. pp. 77-85.

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Abstract

Borophosphate glasses with compositions of (48 - x)P2O5-(12 + x)B2O3-14CaO-20MgO-1Na(2)O-5Fe(2)O(3) (where x = 0, 3, 8 mol%) were prepared via a melt -quenching process. The effects of replacing P2O5 with B2O3 on the structural, thermal, degradation properties and cytocompatibility were investigated. Fourier transform infrared (FTIR) spectroscopy analysis confirmed the existence of BO3 triangular units and BO4 tetrahedral units within all the glasses with an increase of B/P ratio from 0.25 to 0.5. The BO4 units within the glass structure were observed to cause an increase in density (rho) as well as glass transition (T-g) temperature and to decrease the crystallisation temperature (T-c). A decrease in thermal stability which indicated by process window was also observed in the case of substitution of P2O5 with B2O3. Degradation analysis of the glasses indicated that the dissolution rate increased with the addition of B2O3. The decrease in the thermal stability and chemical durability were attributed to the increase of BO3 units, Which could increase crystallisation tendency and be easily hydrolysed by solution. The effect of boron addition on the cytocompatibility of the glasses was analysed using Alamar Blue and alkaline phosphatase (ALP) assays and DNA quantification. MG63 osteosarcoma cells cultured in direct contact with the glass samples surface for 14 days showed better cytocompatibility, compared to the tissue culture plastic (TCP) control group. In summary, the glass formulation with 12 mol% B2O3 presented the best cytocompatibility and thermal stability, thus could be considered for continuous fibre fabrication in future research and downstream activities. (C) 2016 Elsevier B.V. All rights reserved.

Item ID: 58011
Item Type: Article (Research - C1)
ISSN: 0022-3093
Keywords: borophosphate glass, thermal properties, glass structure, degradation, cytocompatibility
Copyright Information: © 2016 Elsevier B.V. All rights reserved.
Date Deposited: 17 Apr 2019 09:23
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091202 Composite and Hybrid Materials @ 100%
SEO Codes: 88 TRANSPORT > 8803 Aerospace Transport > 880399 Aerospace Transport not elsewhere classified @ 0%
86 MANUFACTURING > 8610 Ceramics, Glass and Industrial Mineral Products > 861005 Structural Glass and Glass Products @ 100%
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