Scotchford, C.A., Shataheri, M., Chen, P.-S., Evans, M., Parsons, A.J., Aitchison, G.A., Efeoglu, C., Burke, J.L., Vikram, A., Fisher, S.E., and Rudd, C.D. (2011) Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants. Journal of Biomedical Materials Research Part A, 96A (1). pp. 230-238.

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Abstract

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials.

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