Modifiable risk-factors for keratinocyte cancers in Australia: a case-control study

Serna-Higuita, Lina Maria, Harrison, Simone L., Buttner, Petra, Glasby, Margaret, Raasch, Beverly A., Iftner, Angelika, Garbe, Claus, Martus, Peter, and Iftner, Thomas (2019) Modifiable risk-factors for keratinocyte cancers in Australia: a case-control study. Acta Dermato-Venereologica, 99 (4). pp. 404-411.

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Keratinocyte cancer is the most common malignancy in Caucasians. The aim of this study was to investigate risk-factors responsible for development of keratinocyte cancer in Australia. A case-control study was conducted, including 112 cases of squamous cell carcinoma (SCC), 95 cases of basal cell carcinoma (BCC) and 122 controls. Freckling during adolescence (SCC: odds ratio (OR) 1.04, p < 0.01; BCC: OR 1.05, p < 0.01), propensity to sunburn (SCC: OR 2.75, p = 0.01, BCC: OR 2.68 p = 0.01) and high cumulative sun-exposure (SCC: OR 2.43, p = 0.04; BCC: OR 2.36 p = 0.04) were independent risk-factors for both SCC and BCC. This study provides further evidence that a sun-sensitive phenotype and excessive sun-exposure during adulthood contribute to the risk of developing keratinocyte cancer. Wearing a hat, long-sleeved shirts, and sunscreen did not significantly reduce the risk of keratinocyte cancer in this study.

Item ID: 57916
Item Type: Article (Research - C1)
ISSN: 0001-5555
Keywords: risk factor, keratinocyte cancer, sunlight, sunscreen, basal cell cancer, squamous cell cancer
Copyright Information: Journal Compilation © 2019 Acta Dermato-Venereologica. This is an Open Access article distributed under the terms of a Creative Commons Attribution non-Commercial international license.
Funders: Cancer Council Queensland, Parkes Bequest, Townsville Hospital, Deutsche Forschungsgemeinschaft (DFG), University of Tubingen
Projects and Grants: CCQ John McCaffrey Fellowship for Cancer Control in North Queensland, University of Tubingen Open Access Publishing Fund
Date Deposited: 10 Apr 2019 07:45
FoR Codes: 42 HEALTH SCIENCES > 4202 Epidemiology > 420299 Epidemiology not elsewhere classified @ 70%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 30%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920401 Behaviour and Health @ 100%
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