Gametocytocidal drugs: taking the population perspective

Graves, Patricia, Gelband, Hellen, Garner, Paul, and Choi, Leslie (2018) Gametocytocidal drugs: taking the population perspective. Lancet Infectious Diseases, 18 (7). p. 719.

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DOI: 10.1016/S1473-3099(18)30337-2

View at Publisher Website: https://doi.org/10.1016/S1473-3099(18)30...

Abstract

[Excerpt] In their Article Dicko and colleagues¹ state that both primaquine and methylene blue were "highly efficacious for preventing Plasmodium falciparum transmission" when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.

Research Statement

Research Background	This is a letter in response to publications relevant to a systematic review by the same group of authors
Research Contribution	All authors contributed equally
Research Significance	This is relevant to a WHO treatment guidelines and policy.

Item ID:	57861
Item Type:	Article (Commentary)
ISSN:	1474-4457
Date Deposited:	06 Apr 2020 22:17
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes:	92 HEALTH > 9202 Health and Support Services > 920204 Evaluation of Health Outcomes @ 50% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 50%
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