Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

Huynh, Pacific, and Chai, Zhonglin (2019) Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD). Clinical Science, 133 (2). pp. 287-313.

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Abstract

The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are currently no effective treatments available to sufficiently halt the progression of CKD towards renal failure. This is largely due to ongoing secondary pathological processes generally elicited by the onset of disease. Fibrosis, in particular, is a prominent pathological hallmark of many forms of CKD and considered to be a central contributing factor for the progression of CKD towards end-stage renal disease. Transforming growth factor β (TGFβ) has been implicated to be a major regulatory cytokine in CKD, especially in fibrosis development, and reduced TGFβ signalling activity has been previously shown to be associated with improved renal outcomes in experimental animal studies. A number of molecules related to and/or interacting with the TGFβ signalling pathway have been identified as potential therapeutic targets. However, due to its pleiotropic nature, complete inhibition of the TGFβ signalling pathway is likely to lead to deleterious side effects. Therefore, a better understanding of this pathway and the molecules modulating this pathway is necessary to develop more efficacious and therapeutic strategies to combat progression of CKD.

Item ID: 57840
Item Type: Article (Research - C1)
ISSN: 1470-8736
Copyright Information: © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Funders: National Health and Medical Research Council (NHMRC), National Heart Foundation of Australia (NHF), Diabetes Australia, Juvenile Diabetes Research Foundation (JDRF)
Projects and Grants: NHMRC grant number APP1060450, NHF grant nuber G07M3245, JDRF grant number 27-2009-417
Date Deposited: 03 Apr 2019 07:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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