Variability of Symmetric Dimethylarginine in apparently healthy dogs

Kopke, M.A., Burchell, R.K., Ruaux, C.G., Burton, S.E., Lopez-Villalobos, N., and Gal, A. (2018) Variability of Symmetric Dimethylarginine in apparently healthy dogs. Journal of Veterinary Internal Medicine, 32. pp. 736-742.

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Background: Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published populationbased reference intervals.

Hypothesis/Objectives: To determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

Animals: Twenty apparently healthy adult dogs owned by clients or staff at a veterinary teaching hospital.

Methods: Prospective, observational study. Blood was collected from each dog on 9 occasions, and SDMA and sCr were measured in duplicate using commercially available assays.

Results: SDMA and sCr had intermediate and low IOI values of 0.87 and 0.28, respectively. The CD of SDMA and sCr, was 1.34 mg/dL and 0.89 mmol/L, respectively. The sample numbers required for estimation of an individual’s HSP (with 90 and 95% CI) for SDMA and sCr were 8 and 45, and 2 and 12 sequential measurements, respectively.

Conclusions and Clinical Importance: Based on our findings, in comparison to sCr, SDMA is better suited for use with population based reference intervals. False-negative test results could occur when comparing a single test result from an individual to such intervals. Ideally CD should be used with sequential measurements.

Item ID: 57441
Item Type: Article (Research - C1)
ISSN: 1939-1676
Copyright Information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Date Deposited: 13 Mar 2019 22:46
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300904 Veterinary diagnosis and diagnostics @ 100%
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