Cross-border movement of highly drug-resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015

Bainomugisa, Arnold, Pandey, Sushi, Donnan, Ellen, Simpson, Graham, Foster, J'Belle, Lavu, Evelyn, Hiasihri, Stenard, McBryde, Emma S., Moke, Rendi, Vincent, Steven, Sintchenko, Vitali, Marais, Ben J., Coin, Lachlan J.M., and Coulter, Christopher (2019) Cross-border movement of highly drug-resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015. Emerging Infectious Diseases, 25 (3). pp. 406-415.

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Abstract

In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.

Item ID: 57331
Item Type: Article (Research - C1)
ISSN: 1080-6059
Copyright Information: Emerging Infectious Diseases is an open access journal in the public domain. All content is freely available without charge to the user or his/her institution. Materials published in EID, including text, figures, tables, and photographs, can be reprinted or reused although the journal requests a proper citation be included for its content and users clearly indicate what, if any, changes have been made.
Date Deposited: 06 Mar 2019 07:43
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100%
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