Relationship between serum omega-3 fatty acid and asthma endpoints
Adams, Shahieda, Lopata, Andreas L., Smuts, Cornelius M., Baatjies, Roslynn, and Jeebhay, Mohamed F. (2019) Relationship between serum omega-3 fatty acid and asthma endpoints. International Journal of Environmental Research and Public Health, 16 (1). 43.
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Abstract
Recent studies have highlighted the potential protective role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in asthma. This study aimed at determining the association between seafood intake, serum PUFA composition and clinical endpoints of asthma in adults. A cross-sectional study of 642 subjects used the European Committee Respiratory Health Survey (ECRHS) questionnaire, skin prick tests, spirometry and methacholine challenge tests following ATS guidelines. Sera was analysed for n-3 and n-6 PUFA composition. Subjects had a mean age of 34 years, were largely female (65%) and 51% were current smokers. While 99% reported fish consumption, rock lobster, mussels, squid and abalone were also consumed less frequently. The prevalence of asthma symptoms was 11%, current asthma (ECRHS definition) was 8% and non-specific bronchial hyperresponsiveness (NSBH) was much higher (26%) In adjusted models the n-3 PUFAs 20:5 (EPA) and 22:5 (DPA) were significantly associated with a decreased risk of having NSBH. Total n-3 PUFA composition was associated with decreased NSBH risk (OR = 0.92), while high n-6 PUFA composition was associated with an increased risk (OR = 1.14).
| Item ID: | 57324 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1660-4601 |
| Keywords: | non-specific bronchial hyperresponsiveness, polyunsaturated fatty acids, omega-3 fatty acids, omega-6 fatty acids, seafood, allergy, asthma clinical endpoints |
| Copyright Information: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
| Funders: | South African Medical Research Council, National Institute for Occupational Health and Safety (NIOHS) |
| Projects and Grants: | NIOHS R01 Grant F002304 |
| Date Deposited: | 06 Mar 2019 07:38 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320504 Medical biochemistry - lipids @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 50% 42 HEALTH SCIENCES > 4206 Public health > 420603 Health promotion @ 20% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 70% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920408 Health Status (e.g. Indicators of Well-Being) @ 30% |
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