The role of antimalarial quality in the emergence and transmission of resistance

Brock, Aleisha R., Ross, Joshua V., Parikh, Sunil, and Esterman, Adrian (2018) The role of antimalarial quality in the emergence and transmission of resistance. Medical Hypotheses, 111. pp. 49-54.

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Abstract

The emergence and transmission of antimalarial resistance is hampering malaria eradication efforts and is shortening the useful therapeutic life of currently available antimalarials. Drug selection pressure has been identified as a contributing factor to the emergence and transmission of resistance, especially population treatment coverage and sub-therapeutic concentrations of active pharmaceutical ingredient (API) in the bloodstream. Medicine quality can be defined as good quality or poor quality. Poor quality antimalarials can be falsified, substandard or degraded and are estimated to make up between 10 and 50% of the antimalarial market in developing countries, and can be a source of sub-therapeutic doses of antimalarial API(s). The availability and use of poor quality antimalarials and the non-recommended use of quality assured monotherapies have historically been linked to treatment failure and in some cases, have coincided with the emergence and transmission of resistance in regions. We propose and outline the hypotheses that the use of poor quality antimalarial treatments and non-recommended quality assured monotherapies promote the (i) emergence and/or (ii) transmission of antimalarial resistance.

Item ID: 57304
Item Type: Article (Research - C1)
ISSN: 1532-2777
Copyright Information: Copyright © 2017 Elsevier Ltd. All rights reserved.
Funders: University of South Australia (USA)
Projects and Grants: USA Australia Postgraduate Award
Date Deposited: 05 Mar 2019 04:30
FoR Codes: 42 HEALTH SCIENCES > 4203 Health services and systems > 420315 One health @ 25%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 25%
49 MATHEMATICAL SCIENCES > 4901 Applied mathematics > 490102 Biological mathematics @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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