Hellier, C., Newell, S., Barry, J., and Brimacombe, J. (2003) A 5-um filter does not reduce propofol-induced pain. Anaesthesia, 58 (8). pp. 802-803.

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Abstract

We assessed the effectiveness of a 5-μm filter in reducing propofol-induced pain and determined whether any reduction is due to removal of contaminants or an alteration in flow characteristics. A total of 120 unpremedicated women (ASA 1-3, aged 18-70 yr) were randomly allocated to one of three equal-sized groups. In group A, propofol was drawn up and injected through an unfiltered plastic cannula. In group B, propofol was drawn up through a 5-μm filter needle and injected through an unfiltered plastic cannula. In group C, propofol was drawn up and injected through a 5-μm filter needle. Unmodified propofol from a 20-ml rubber topped vial at room temperature was used. A 22-g cannula was inserted into the largest visible vein on the dorsum of the non-dominant hand. Propofol was administered at 0.5 ml.s−1 and patients were asked about pain every 10 s until unresponsive, by a blinded observer. The pain score for the patient was the taken as the most severe pain documented. The frequency and severity of pain were similar among groups. We conclude that a 5-μm filter does not reduce pain associated with injection of propofol drawn from a vial with a rubber bung.

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