Opisthorchis viverrini proteome and host-parasite interactions

Suttiprapa, Sutas, Sotillo, Javier, Smout, Michael, Suyapoh, Watcharapol, Chaiyadet, Sujittra, Tripathi, Timir, Laha, Thewarach, and Loukas, Alex (2018) Opisthorchis viverrini proteome and host-parasite interactions. In: UNSPECIFIED, (ed.) Advances in Parasitology. Advances in Parasitology, 102 . Elsevier, London, UK, pp. 45-72.

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The omics technologies have improved our understanding of the molecular events that underpin host–parasite interactions and the pathogenesis of parasitic diseases. In the last decade, proteomics and genomics in particular have been used to characterize the surface and secreted products of the carcinogenic liver fluke Opisthorchis viverrini and revealed important roles for proteins at the host–parasite interface to ensure that the flukes can migrate, feed and reproduce in a hostile environment. This review summarizes the advances made in this area, primarily focusing on discoveries enabled by the publication of the fluke secreted proteomes over the last decade. Protein families that will be covered include proteases, antioxidants, oncogenic proteins and the secretion of exosome-like extracellular vesicles. Roles of these proteins in host–parasite interactions and pathogenesis of fluke-induced hepatobiliary diseases, including cholangiocarcinogenesis, are discussed. Future directions for the application of this knowledge to control infection and disease will also be discussed.

Item ID: 57252
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-12-815191-4
ISSN: 2163-6079
Keywords: cholangiocarcinoma; extracellular vesicle; helminth; host–parasite interaction; opisthorchis viverrini; OvES
Copyright Information: Copyright © 2018 Elsevier Ltd. All rights reserved.
Funders: Thailand Research Fund (TRF), National Health and Medical Research Council of Australia (NHMRC)., US National Cancer Institute (USNCI)
Projects and Grants: TRF TRG5780147, NHMRC 1117504, NHMRC 1085309, USNCI R01CA164719
Date Deposited: 04 Mar 2019 22:25
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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