Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior

Giacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengsston, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán, and Soares Magalhães, Ricardo J. (2018) Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior. Journal of Infectious Diseases, 218 (9). pp. 1511-1516.

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Abstract

Helminth infections in children are associated with impaired cognitive development; however, the biological mechanisms for this remain unclear. Using a murine model of gastrointestinal helminth infection, we demonstrate that early-life exposure to helminths promotes local and systemic inflammatory responses and transient changes in the gastrointestinal microbiome. Behavioral and cognitive analyses performed 9-months postinfection revealed deficits in spatial recognition memory and an anxiety-like behavioral phenotype in worm-infected mice, which was associated with neuropathology and increased microglial activation within the brain. This study demonstrates a previously unrecognized mechanism through which helminth infections may influence cognitive function, via perturbations in the gut-immune-brain axis.

Item ID: 57139
Item Type: Article (Research - C1)
ISSN: 1537-6613
Keywords: cognition; helminth; inflammation; microbiome
Copyright Information: Copyright © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC grant APP1105420
Date Deposited: 19 Feb 2019 04:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 60%
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