Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior
Giacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengsston, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán, and Soares Magalhães, Ricardo J. (2018) Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior. Journal of Infectious Diseases, 218 (9). pp. 1511-1516.
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Abstract
Helminth infections in children are associated with impaired cognitive development; however, the biological mechanisms for this remain unclear. Using a murine model of gastrointestinal helminth infection, we demonstrate that early-life exposure to helminths promotes local and systemic inflammatory responses and transient changes in the gastrointestinal microbiome. Behavioral and cognitive analyses performed 9-months postinfection revealed deficits in spatial recognition memory and an anxiety-like behavioral phenotype in worm-infected mice, which was associated with neuropathology and increased microglial activation within the brain. This study demonstrates a previously unrecognized mechanism through which helminth infections may influence cognitive function, via perturbations in the gut-immune-brain axis.
| Item ID: | 57139 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1537-6613 |
| Keywords: | cognition; helminth; inflammation; microbiome |
| Copyright Information: | Copyright © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. |
| Funders: | National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | NHMRC grant APP1105420 |
| Date Deposited: | 19 Feb 2019 04:36 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 40% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 30% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 40% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 60% |
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